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Authors
Affiliations
1 PG Department of Chemistry, Berhampur University, Bhanja Vihar-760007, IN
2 S.B.R. Govt. Women’s (Auto) College, Berhampur-760001, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 539-543
Abstract
Both acridone and its semicarbazone derivative being insoluble in polar medium, may have poor pharmacological activity. To enhance bio-accessibility of these drugs, the inclusion complexes of acridone and its derivative have been prepared with β-cyclodextrin. The spectral characteristics (UV-Vis, FTIR) of these compounds have been studied with and without inclusion complex formation. The phase solubility studies reveal 1:1 stoichiometry between guest and host. The determination of thermodynamic stability constants indicates weak intermolecular forces between the compounds and β-cyclodextrin. The thermodynamic parameters ΔG, ΔH, ΔS of the complexes have been calculated, the values of which suggest that complex formation is spontaneous and exothermic in nature. The antimicrobial activity of acridone and its semicarbazone derivative along with their inclusion complexes against the microbes like Escherichia coli an, Pseudomonas aeruginosa have been studied.
Keywords
Acridone Semicarbazone, Inclusion Complex, Thermodynamic Stability, Antimicrobial Study.
